Description of the drug
Neotigazone is a systemic retinoid based on acitretin, a derivative of vitamin A, used for the treatment of severe dermatological diseases such as psoriasis, ichthyosis, lichen erythematosus, Darye’s disease and hyperkeratosis. The drug helps to restore the structure of the skin and normalizes the processes of its keratinization, thereby alleviating the symptoms of diseases. In 2021, the drug was removed from registration in Russia, which made it inaccessible to patients. Nevertheless, many are looking for information about it, as acitretin and its analogues remain in demand in dermatology (Medside.ru , GidMed).
Indications for use
The drug is prescribed for the following diseases:
severe psoriasis, which is not amenable to other treatment methods;
hereditary keratinization of the skin (for example, ichthyosis);
hyperkeratosis, Darye’s disease;
lichen planus and other conditions accompanied by a significant violation of the skin structure.
As a rule, Neotigazone is prescribed only in cases where other drugs do not have the desired effect. Taking the drug requires mandatory medical supervision and careful monitoring of the patient’s condition (RLSnet).
Method of application and dosage
Neotigazone is taken orally, 1 time per day, preferably with meals. The dose is determined by the doctor based on the patient’s condition and his reaction to the drug. The usual initial dose for adults is 25-30 mg per day, with possible adjustment depending on the therapeutic effect and tolerability. The drug is prescribed to children extremely rarely and only in exceptional cases under the strict supervision of a doctor.
Side effects and possible risks
Neotigazone causes a wide range of adverse reactions. Among the most frequent:
Dryness of the skin and mucous membranes. Most often it manifests itself on the lips, facial skin and nasal cavity;
Headaches, photosensitivity, visual impairment in the dark;
Increased cholesterol and lipid levels in the blood. This requires regular laboratory monitoring;
Bone and muscle pain, which is often observed with prolonged use.
The drug has a pronounced teratogenic effect, that is, it is capable of causing severe defects in the fetus. Therefore, it is categorically contraindicated for pregnant women and women planning pregnancy in the near future. After the end of treatment, it is important to use reliable methods of contraception for two years, since acitretin can form etretinate when interacting with alcohol, which is excreted from the body for a long time and also has a teratogenic effect (fb.ru ).
Precautions
To minimize side effects, it is recommended:
Monitor the lipid profile and liver function before and during treatment;
Avoid sunlight and use sunscreens, as the drug increases the photosensitivity of the skin;
Use moisturizers and skin care products during treatment to reduce dryness of the skin and lips;
Mandatory contraception for women of childbearing age before, during and after the course of taking the drug.
Analogues and possible substitutes
Since Neotigazone has been removed from registration, patients and doctors have to select alternative drugs. Other retinoids can be used as analogues, such as:
Acitretin, a derivative of vitamin A, with a similar effect, but under other trade names;
Isotretinoin (used in severe forms of acne and some skin diseases);
Etretinate — although not so common, it also has a similar effect.
However, analogues should be selected strictly with a doctor, since each drug has individual characteristics, possible side effects and contraindications (Nebolеem.net ).
Prices
Before being de-registered, the price of Neotigazone in Russia ranged from 3,500 to 8,000 rubles per package, depending on dosage and region. The packages contained 30 capsules of 10 or 25 mg each. Analogues of the drug in pharmacy chains today have approximately the same price, which requires consideration when prescribing treatment.
Patient reviews and doctors’ opinions
Patient reviews of Neotigazone indicate its high efficacy in psoriasis and other chronic skin diseases, however, a significant number of side effects reduce the convenience and safety of treatment. Patients often notice an improvement in their skin condition, but many face side effects such as dry skin and lips, headaches, photosensitivity and joint pain. Doctors warn that the drug should be used strictly according to its intended purpose and under the supervision of a specialist, especially for patients with chronic liver, kidney diseases or with high levels of lipids in the blood (Medside.ru , GidMed).
Conclusion
Neotigazone is a powerful and effective remedy for the treatment of complex skin diseases, but its use requires strict safety and control measures. Before starting treatment, a doctor’s consultation is required, as well as regular examination to minimize the risk of complications. The use of acitretin and its analogues requires strict adherence to the instructions and recommendations of the doctor, especially for patients with concomitant diseases.
